DISTRIBUTION OF THE LABELED [¹²³I] PEPTIDE-PROTEIN DRUG CELLEX IN RATS
Abstract
The aim of this work was to study the distribution of the labeled 123I peptide-protein drug Cellex in organs and tissues of rats after single intravenous injection and accumulation. After a single intravenous injection of radiolabeled [123I]Cellex it was found that the drug is characterized by rapid distribution into tissues and organs. The highest content of the drug in all organs and tissues was observed in 15 minutes after its administration. It was established that the drug penetrates the blood-brain barrier and about 6% of the drug accumulates in the brain, which is 10% of the total amount of the drug found in all organs in 15 minutes after administration.
About the Authors
I. N. Urakova
St.-Petersburg Institute of Pharmacy
Russian Federation
Russian Federation
O. N. Pozharitskaya
St.-Petersburg Institute of Pharmacy
Russian Federation
Russian Federation
V. J. Sukhov
S. M. Kirov Military Medical Academy (MMA)
Russian Federation
Russian Federation
M. N. Makarova
St.-Petersburg Institute of Pharmacy
Russian Federation
Russian Federation
A. N. Shikov
St.-Petersburg Institute of Pharmacy
Russian Federation
Russian Federation
V. G. Makarov
St.-Petersburg Institute of Pharmacy
Russian Federation
Russian Federation
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Review
For citations:
Urakova I.N., Pozharitskaya O.N., Sukhov V.J., Makarova M.N., Shikov A.N., Makarov V.G. DISTRIBUTION OF THE LABELED [¹²³I] PEPTIDE-PROTEIN DRUG CELLEX IN RATS. Drug development & registration. 2018;(4):89-94. (In Russ.)
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