Preview

Drug development & registration

Advanced search

The Method of Express Measurement of Moisture of Bulk Material During Pneumo Transport Process in the Pharmaceutical Industry, Based on the Pockels Effect (Review)

https://doi.org/10.33380/2305-2066-2019-8-3-40-43

Abstract

Introduction. The article presents data on the development and implementation of a method for measuring the moisture content of bulk material during its pneumatic transport in pharmaceutical production. The method of measuring moisture is theoretically based on the physical Pockels effect. An analysis of the currently existing pharmacopoeial methods for monitoring the quantitative water content and methods of in-process control of the drying process is presented. The development of new methods and technical means that provide the necessary speed and accuracy of moisture measurement is an important task, especially in the pharmaceutical industry to control the residual moisture of the starting materials, intermediate products during their production and finished products.

Text. Analysis of the theoretical assumptions for the method and technical systems for measuring the mass of bulk dielectric materials during their pneumatic conveying shows the ability to measure the moisture content of the bulk dielectric material transported by air through a pipeline in a new non-contact manner. The proposed method is based on one measurable parameter – the intensity of the light wave passing through the Pockels cell. A block diagram of the system developed by the authors for automated moisture measurement of bulk dielectric materials with an electrooptical Poсkels cell is presented. The article describes a method for measuring moisture, based on the Pockels effect, for bulk material during its pneumatic transport.

Conclusion. The proposed method of measuring moisture is contactless, just technically feasible, has a high speed and measurement accuracy, since it is based on the Pockels effect. The method is universal for determining the moisture content of bulk dielectric materials in the process of their pneumatic transportation. The above advantages of this method suggest the possibility of its successful application in pharmaceutical production.

About the Authors

V. G. Gulyaev
Federal State Budgetary Educational Institution of Higher Education «Nizhny Novgorod State University of Architecture and Civil Engineering»
Russian Federation

65, Ilinskaya str., N. Novgorod, 603950



I. V. Gulyaev
Federal State Institution «State Institute of Drugs and Good Practices»
Russian Federation

6, Lavrov lane, Moscow, 109044



References

1. OFS.1.2.3.002.15 «Determination of water». State Pharmacopoeia of the Russian Federation. 14th ed. M .: Scientific Center for Expertise of Medical Applications, 2018. Available at: http://femb.ru/femb/pharmacopea.php.

2. European Pharmacopoeia: EDQM. 9th Edition. 2.5.32. «Water: micro determination».

3. European Pharmacopoeia: EDQM. 9th Edition. 2.5.12. «Water: semimicro determination».

4. European Pharmacopoeia: EDQM. 9th Edition. 2.2.13. «Determination of water by distillation».

5. USP 40 <921> «Water determination». Available at: https://hmc.usp.org/sites/default/files/documents/HMC/GCs-Pdfs/c921.pdf.

6. OFS.1.2.1.0010.15 «Loss in weight during drying». State Pharmacopoeia of the Russian Federation. 14th ed. M.: Scientific Center for Expertise of Medical Applications, 2018. Available at: http://femb.ru/femb/pharmacopea.php.

7. European Pharmacopoeia: EDQM. 9th Edition. 2.2.32. «Loss on drying».

8. USP 40 <731> «Loss on drying». Available at: https://hmc.usp.org/sites/default/files/documents/HMC/GCs-Pdfs/c731.pdf.

9. Am Ende D.J. et all. Production of medicines. Chemical technology from R&D to production: Per. from English / Ed. V. V. Beregovykh. – SPb.: CSC «Profession», 2015: 1280 p.

10. Burgbacher J., Wiss. J. Industrial applications of online monitoring of drying processes of drug substances using NIR. Org. Process Res. Dev. 2008; 12: 235–242.

11. Cypes S. H., Wenslow R. M., Thomas S. M., Chen A. M., Dorwart J. G., Corte J. R., Kaba M. Drying an organic monohydrate: crystal form instabilities and a factory-scale drying scheme to ensure monohydrate preservation. Org. Process Res. Dev. 2004; 8: 576–582.

12. Patent 2518514 of the Russian Federation A method for measuring the flow rate of a two-phase flow of a dielectric material that is transported by air through a metal pipeline. Gulyaev V. G., Plotnikov N. M., Plotnikov M. M. Nizhegor. State Architecture.-build. un-t Publ. 04.11.2014.

13. Patent 2565348 of the Russian Federation Measuring instrument of a flow of a two-phase stream of dielectric materials moved by air on the metal pipeline. Gulyaev V. G., Gulyaev I. V. Nizhegor. State Architecture.-build. un-t Publ. 20.10.2015.

14. Gulyaev V. G. Measurement of flow of bulk dielectric materials transported by air in closed pipelines. Devices. 2011; 1 (127): 35–39.

15. Gulyaev V. G., Gulyaev I.V. A method for measuring the amount of pneumatically transportable bulk material in pharmaceutical production, based on the Pockels effect. Drug development & registration. 2018; 2 (23): 52–56.

16. Gulyaev V. G., Gulyaev I. V. Methods of improving the performance of the flow meter of pneumatic-transported bulk materials. Volga scientific journal. 2013; 3: 24–29.


Review

For citations:


Gulyaev V.G., Gulyaev I.V. The Method of Express Measurement of Moisture of Bulk Material During Pneumo Transport Process in the Pharmaceutical Industry, Based on the Pockels Effect (Review). Drug development & registration. 2019;8(3):40-43. (In Russ.) https://doi.org/10.33380/2305-2066-2019-8-3-40-43

Views: 1353


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2305-2066 (Print)
ISSN 2658-5049 (Online)