STANDARDIZATION OF INCLUSION COMPLEX OF DISULFIRAM WITH HYDROXYPROPYL-β-CYCLODEXTRIN FOR USE AS PHARMACEUTICAL SUBSTANCES
Abstract
The State Pharmacopoeia XIII sets out the main principles of quality of pharmaceutical substances listed parametrs that should be included in the regulatory documents, given the characteristics of these indicators and recommendations for their regulation. Input quality control performance and valuation limits must comply with the appointment of the pharmaceutical substance. This paper presents the key indicators that can be used to standardize the inclusion complex of disulfiram with hydroxypropyl-β-cyclodextrin for later use as a pharmaceutical substance.
About the Authors
S. A. Kedik
Moscow Technological University (MITHT);
CJSC Institute of Pharmaceutical Technologies
Russian Federation
Russian Federation
A. V. Panov
Moscow Technological University (MITHT);
CJSC Institute of Pharmaceutical Technologies
Russian Federation
Russian Federation
V. S. Tyukova
Moscow Technological University (MITHT);
CJSC Institute of Pharmaceutical Technologies
Russian Federation
Russian Federation
References
1. Дисульфирам (Disulfiramum) // Интернет-справочник лекарств. URL: http://avitsena.com.ua/ru/spravochnik_lekarstv/d/disulfiram.html (дата обращения 15.05.2015).
2. L.P. Rybak, R. Ravi, S.M. Somani. Mechanism of protection by diethyldithiocarbamate against cisplatin ototoxicity: antioxidant system // Fundamental and applied toxicology. 1995. V. 26. P. 293-300.
3. A.L. Zanocco, R. Pavez, L.A. Videla, E.A. Lissi. Antioxidant capacity of diethylthiocarbamate in a metal-independent lipid peroxidase process // Radical Biology & Medicine. 1989. V. 7. P. 151-156.
4. N. Nagai, M. Takeda, Y. Ito, N., Takeuchi A. Kamei. Delay in ICR/f rat lens opacification by the instillation of eye drops containing disulfiram and hydroxypropyl-b- cyclodextrin inclusion complex // Biol. Pharm. Bull. 2007. V. 30(8). P. 1529-1534.
5. N. Nagai, Y. Ito, N. Takeuchi. Effect of disulfiram eye drops on lipid peroxide formation via excessive nitric oxide in lenses of hereditary cataract ICR/f rats // Biol. Pharm. Bull. 2008. V. 31(5). P. 981-985.
6. N. Nagai, Y. Ito, N. Takeuchi. Pharmacokinetic and pharmacodynamic evaluation of the anti-cataract effect of eye drops containing disulfiram and low-substituted methylcellulose using ICR/f rats as a hereditary cataract model // Biol. Pharm. Bull. 2012. V. 35. № 2. P. 239-245.
7. S. Göktürk, E. Calıskan, R.Y. Talman, U. Var. A study on solubilization of poorly soluble drugs by cyclodextrins and micelles: complexation and binding characteristics of sulfamethoxazole and trimethoprim // The Scientific World Journal. 2012. V. 2012. 12 р.
8. A. Chaudhary, U. Nagaich, N. Gulati, V.K. Sharma, R.L. Khosa. Poorly water soluble drugs: change in solubility for improved dissolution characteristics a review // Journal of Advanced Pharmacy Education & Research. 2012. V. 2. № 1. P. 32-67.
9. T. Loftsson, D. Duchene. Historical perspectives cyclodextrins and their pharmaceutical applications // International Journal of Pharmaceutics. 2007. V. 329. Р. 1-11.
10. С.А. Кедик, В.С. Тюкова, Е.С. Жаворонок, А.В. Панов, В.В. Бондарь. Новый способ получения комплекса включения на основе дисульфирама с гидрокси-пропил-бэта-циклодекстрином // Биофармацевтический журнал. 2015. Т. 7. № 4. С. 19-23.
Review
For citations:
Kedik S.A., Panov A.V., Tyukova V.S. STANDARDIZATION OF INCLUSION COMPLEX OF DISULFIRAM WITH HYDROXYPROPYL-β-CYCLODEXTRIN FOR USE AS PHARMACEUTICAL SUBSTANCES. Drug development & registration. 2016;(2):104-107. (In Russ.)
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