ULTRASTRUCTURE OF RAT LIVER AND LUNGS AFTER SINGLE INTRAVENOUS INJECTION OF MAGNITOMICELLS BASED CARBON-COATED IRON NANOPARTICLES
Abstract
In this study the effect of magnitomicells based on carbon incapsulated iron nanoparticles on the ultrastructure of rat’s liver and lungs after intravenous injection of their aqueous suspensions was investigated. Deducing of animal from the experiment was conducted in 1st and 40th days after intravenous injection of suspensions of nanoparticles. Ultrastructural examination of the liver and lung of rats was performed with a transmission electron microscope. Ultrastructural signs of damage of hepatocytes, pneumocytes and mononuclear phagocytes are not detected.
About the Authors
G. U. Vasukov
Department of morphology and general pathology of Siberian State Medical University;
Laboratory of ultrastructural methods of investigating of tissues, department of experimental and clinical cardiology, institute of complex problems of cardio-vascular diseases of Siberian department of Russian Academy of Medical Science
Russian Federation
Russian Federation
I. V. Milto
Department of morphology and general pathology of Siberian State Medical University;
Department of biotechnology and organic chemistry of National Research Tomsk Polytechnic University
Russian Federation
Russian Federation
I. V. Sukhodolo
Department of morphology and general pathology of Siberian State Medical University
Russian Federation
Russian Federation
I. V. Mitrofanova
Department of morphology and general pathology of Siberian State Medical University;
Laboratory of translational cellular and molecular biomedicine, Tomsk State University
Russian Federation
Russian Federation
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Review
For citations:
Vasukov G.U., Milto I.V., Sukhodolo I.V., Mitrofanova I.V. ULTRASTRUCTURE OF RAT LIVER AND LUNGS AFTER SINGLE INTRAVENOUS INJECTION OF MAGNITOMICELLS BASED CARBON-COATED IRON NANOPARTICLES. Drug development & registration. 2016;(2):146-150. (In Russ.)
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