Thermosensitive polymers in drug delivery systems (review)

D. O. Maslov; M. S. Zolotareva

doi:10.33380/2305-2066-2026-15-2-2085

Thermosensitive polymers in drug delivery systems (review)

D. O. Maslov, M. S. Zolotareva

https://doi.org/10.33380/2305-2066-2026-15-2-2085

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Abstract

Introduction. Water-soluble polymers that are sensitive to temperature are promising for use in pharmaceutical development to create "smart" drug delivery systems.

Text. This review article discusses three groups of thermosensitive polymers: those with a lower critical solution temperature (LCST) and those with an upper critical solution temperature (UCST), as well as polymers exhibiting both types of behavior. The article presents their classification, development features, application examples and modifications to give the necessary properties.

Conclusion. Polymers with LCST and UCST behavior are promising materials for the development of thermosensitive drug delivery systems that are already used in biomedicine.

Keywords

thermosensitive polymers, UCST, LCST, smart polymers, drug delivery

About the Authors

D. O. Maslov

MIREA – Russian Technological University
Russian Federation

86, prospekt Vernadskogo, Moscow, 119571

M. S. Zolotareva

MIREA – Russian Technological University
Russian Federation

86, prospekt Vernadskogo, Moscow, 119571

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For citations:

Maslov D.O., Zolotareva M.S. Thermosensitive polymers in drug delivery systems (review). Drug development & registration. 2026;15(2):72-80. (In Russ.) https://doi.org/10.33380/2305-2066-2026-15-2-2085

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