FORMYLATION OF 2-(METHYLTHIO)PYRIMDINE-4,6-DIOL IN THE REACTIO CONDITIONS OF VILSMEIER-HAAK (SHORT MESSAGE)
Abstract
The reaction of formylation by Vilsmeier - Haack was held. The effect of excess phosphorus oxychloride in the direction of the reaction. Optimal conditions were conducting formylation reaction to obtain a single compound with a high yield. The result of the reaction product mixture was conducted chromatographic separation on a column packed with silica gel 60 Silica.
About the Authors
E. S. Ofitserova
Federal State Budgetary Educational Institution of Higher Education "Saint-Petersburg State Chemical-Pharmaceutical Academy" of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
A. A. Shklyarenko
Federal State Budgetary Educational Institution of Higher Education "Saint-Petersburg State Chemical-Pharmaceutical Academy" of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
I. P. Yakovlev
Federal State Budgetary Educational Institution of Higher Education "Saint-Petersburg State Chemical-Pharmaceutical Academy" of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
E. V. Fedorova
Federal State Budgetary Educational Institution of Higher Education "Saint-Petersburg State Chemical-Pharmaceutical Academy" of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
References
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2. A.A. Santilli., D.H. Kim, S.V. Wanser // J. Heterocycl. chem. 1971. V. 8. P. 445-453.
3. Е.С. Офицерова, А.А. Шкляренко, И.П. Яковлев, Е.В. Федорова. Формилирование этил[(4,6-дигидроксипиримидин-2-ил)сульфанил]ацетата в условиях реакции Вильсмейера - Хаака // Журнал органической химии. 2016. № 52. С. 1374-1376.
Review
For citations:
Ofitserova E.S., Shklyarenko A.A., Yakovlev I.P., Fedorova E.V. FORMYLATION OF 2-(METHYLTHIO)PYRIMDINE-4,6-DIOL IN THE REACTIO CONDITIONS OF VILSMEIER-HAAK (SHORT MESSAGE). Drug development & registration. 2017;(1):112-114. (In Russ.)
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