CALORIMETRIC OBTAINING OF PHARMACEUTICAL FORM OF PARACETOMOL
Abstract
The possibility of formation of paracetamol of orthorhombic modification by the method of calorimetry is studied. The studies include technological experiments, optical microscopy, differential scanning calorimetry, X-ray diffraction and IR spectroscopy. It is found that in the result of temperature cycling the crystals of paracetamol are modified in the crystals of orthorhombic syngony. Microphotographs, X-ray diffraction patterns, differential scanning spectroscopy curves and absorption spectra are presented.
About the Authors
A. P. Belyaev
Department of Physical and Colloidal Chemistry. Saint-Petersburg State Chemical Pharmaceutical Academy
Russian Federation
Russian Federation
V. P. Rubets
Department of Analytical Chemistry. Saint Petersburg State Institute of Technology (Technical University)
Russian Federation
Russian Federation
V. V. Antipov
Department of Analytical Chemistry. Saint Petersburg State Institute of Technology (Technical University)
Russian Federation
Russian Federation
References
1. А.В. Душкин, Л.П. Сунцова, С.С. Халиков. Механохимическая технология для повышения растворимости лекарственных веществ // Фундаментальные исследования. 2013. № 1-2. С. 448-457.
2. M. Haisa, S. Kashino, H. Maeda. The orthorhombic form of p-hydroxyacetanilide // Acta Crystallogr. B Struct. Sci. 1974. V. 30. № 10. P. 2510-2512.
3. J.B. Nanubolu, J.C. Burley. Investigating the recrystallization behavior of amorphous paracetamol by variable temperature raman studies and surface raman mapping // Molecular pharmaceutics. 2012. V. 9. № 6. P. 1544-1558.
4. F. Sun, B. Xu, Y. Zhang, S. Dai, X. Shi, Y. Qiao. Latent variable modeling to analyze the effects of process parameters on the dissolution of paracetamol tablet // Bioengineered. 2017. V. 8. № 1. P. 61-70.
5. M.L. Myrick, M. Baranowski, L.T.M. Profeta. An experiment in physical chemistry: Polymorphism and phase stability in acetaminophen (paracetamol) // Journal of Chemical Education. 2010. V. 87. № 8. P. 842-844.
6. T. Delmas, U.V. Shah, M.M. Roberts, D.R. Williams, J.Y.Y. Heng. Crystallisation of the orthorhombic form of acetaminophen: Combined effect of surface topography and chemistry // Powder Technology. 2013. V. 236. P. 24-29.
7. M.A. Perrin, H. Elmaleh, L. Zaske, M.A. Neumann. Crystal structure determination of elusive paracetamol form III // Chemical Communication. 2009. № 22. P. 3181-3183.
8. M.S. Anuar, B.J. Briscoe. Detrimental consequences of the paracetamol tablet elastic relaxation during ejection // Drug development and pharmacy. 2010. V. 36. № 8. P. 972-979.
9. R. Picciochi, H.P. Diogo, D.A. Minas, M.E. Piedade. Thermochemistry of paracetamol // Journal of Thermal Analysis and Calorimetry. 2010. V. 100. № 2. P. 391-401.
10. G.Di. Profio, S. Tucci, E. Curcio, E. Drioli. Controlling polymorphism with membrane-based crystallizers: Application to form I and II of paracetamol // Chem.Mater. 2007. V. 19. № 10. P. 2386-2388.
11. J.S. Capes, R.E. Cameron. Contact line crystallization to obtainmetastable polymorphs // Cryst. Growth Des. 2006. V. 7. № 1. P. 108-112.
12. L.H. Thomas, C. Wales, L. Zhao, C.C. Wilson. Paracetamol form II: an elusive polymorph through facilemulticomponent crystallization routes // Cryst. Growth Des. 2011. V. 11. № 5. P. 1450-1452.
13. C.P. Price, A.L. Grzesiak, A.J. Matzger. Crystalline polymorph selection and discovery with polymer heteronucle // J. Am. Chem. Soc. 2005. V. 127. № 15. P. 5512-5517.
14. K. Chadwick, A. Myerson, B. Trout. Polymorphic control by heterogeneous nucleation a new method for selecting crystalline substrates // Cryst. Eng. Comm. 2011. V. 13. № 22. P. 6625-6627.
15. M. Lang, A.L. Grzesiak, A.J. Matzger. The use of polymer heteronuclei for crystalline polymorph selection // J. Am. Chem. Soc. 2002. V. 124. № 50. P. 14834-14835.
16. M.A. Mikhailenko. Growth of large single crystals of the orthorombic paracetamol // J. Cryst. Growth. 2004. V. 265. P. 616-618.
17. P. Di. Martino, P. Conflan, M. Drache, J.P. Huvenne, A.M. Guyot-Hermann. Preparation and physical characterization of forms II and III of paracetamol // J. Therm. Anal. Calorim. 1997. V. 48. № 3. P. 447-458.
18. F. Giordano, A. Rossi1, R. Bettinil, A. Savioli, A. Gazzaniga, Cs. Novák. // Thermal behavior of paracetamol polymeric excipients mixtures // J. Thermal Analysis and Colorimetry. 2002. V. 68. P. 575-590.
19. A.P. Belyaev, V.P. Rubets, V.V. Antipov. Influence of the Nature of a Condensate Material on Formation of an Ensemble of Islands during Crychemical Synthesis from the Vapor Phase // Semiconductors. 2013. V. 47. № 1. P. 13-15.
20. А.П. Беляев, В.П. Рубец, В.В. Антипов Вертикальный рост кристаллов сульфида кадмия на подложке из кремния // Журнал физической химии. 2017. Т. 91. № 2. С. 345-348.
Review
For citations:
Belyaev A.P., Rubets V.P., Antipov V.V. CALORIMETRIC OBTAINING OF PHARMACEUTICAL FORM OF PARACETOMOL. Drug development & registration. 2017;(2):62-64. (In Russ.)
Views:
667
Email this article 