OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION
Abstract
The process of the synthesis of silicon-containing glycerol derivatives of Si(С3H7O3)4 ∙ 6С3Н8O3
composition was optimized on the example of creation of the experimental industrial technology of the drug substance «Silativit» production. The main criterion of optimization was reducing a time and energy expenditure on carrying out the synthesis, representing heterophase reaction of alcoholysis of initial alkoxysilane by polyol. Optimization was performed on such indicators of process as temperature condition, the mode of removal of an easily volatile product of reaction, the mode of mixture of reactionary weight and type of the used mixing device.
composition was optimized on the example of creation of the experimental industrial technology of the drug substance «Silativit» production. The main criterion of optimization was reducing a time and energy expenditure on carrying out the synthesis, representing heterophase reaction of alcoholysis of initial alkoxysilane by polyol. Optimization was performed on such indicators of process as temperature condition, the mode of removal of an easily volatile product of reaction, the mode of mixture of reactionary weight and type of the used mixing device.
About the Authors
A. A. Boyko
I.Ya. Postovsky Institute of Organic Synthesis of Ural Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
S. V. Mordanov
Chemical Engineering Institute of the Ural Federal University, Department of «Machinery and equipment of chemical plants»
Russian Federation
Russian Federation
T. G. Khonina
I.Ya. Postovsky Institute of Organic Synthesis of Ural Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
O. N. Chupahin
I.Ya. Postovsky Institute of Organic Synthesis of Ural Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
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Review
For citations:
Boyko A.A., Mordanov S.V., Khonina T.G., Chupahin O.N. OPTIMIZATION OF EXPERIMENTAL INDUSTRIAL TECHNOLOGY OF SILICON-CONTAINING DERIVATIVES OF POLYOL SUBSTANCES PRODUCTION. Drug development & registration. 2017;(2):108-114. (In Russ.)
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