SIMULTANEOUS DETERMINATION OF AMINOTRIAZOLE AND TRIAZOLOPYRIMIDINONE - SUBSTRATE AND INTERMEDIATE IN THE SYNTHESIS OF «TRIAZIDE» BY HPLC
Abstract
Method of simultaneous determination of aminotriazole and triazolopyrimidinone using HPLC with UV-detection was developed. For best chromatographic performance Zorbax NH2 amino phase column (Agilent Technologies, USA) was selected. The applicability of the developed method for providing technological control of the 1st stage of «Triazide» production was approved according to the results of validation procedure.
About the Authors
A. V. Baklykov
I.Ya. Postovsky Institute of Organic Synthesis UB of RAS;
Ural Federal University named after the first president of Russia B.N. Yeltsin
Russian Federation
Russian Federation
A. A. Tumashov
I.Ya. Postovsky Institute of Organic Synthesis UB of RAS;
Ural Federal University named after the first president of Russia B.N. Yeltsin
Russian Federation
Russian Federation
S. K. Kotovskaya
I.Ya. Postovsky Institute of Organic Synthesis UB of RAS;
Ural Federal University named after the first president of Russia B.N. Yeltsin
Russian Federation
Russian Federation
E. N. Ulomskiy
I.Ya. Postovsky Institute of Organic Synthesis UB of RAS;
Ural Federal University named after the first president of Russia B.N. Yeltsin
Russian Federation
Russian Federation
G. L. Rusinov
I.Ya. Postovsky Institute of Organic Synthesis UB of RAS;
Ural Federal University named after the first president of Russia B.N. Yeltsin
Russian Federation
Russian Federation
V. L. Rusinov
I.Ya. Postovsky Institute of Organic Synthesis UB of RAS;
Ural Federal University named after the first president of Russia B.N. Yeltsin
Russian Federation
Russian Federation
O. N. Chupahin
I.Ya. Postovsky Institute of Organic Synthesis UB of RAS;
Ural Federal University named after the first president of Russia B.N. Yeltsin
Russian Federation
Russian Federation
V. N. Charushin
I.Ya. Postovsky Institute of Organic Synthesis UB of RAS;
Ural Federal University named after the first president of Russia B.N. Yeltsin
Russian Federation
Russian Federation
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Review
For citations:
Baklykov A.V., Tumashov A.A., Kotovskaya S.K., Ulomskiy E.N., Rusinov G.L., Rusinov V.L., Chupahin O.N., Charushin V.N. SIMULTANEOUS DETERMINATION OF AMINOTRIAZOLE AND TRIAZOLOPYRIMIDINONE - SUBSTRATE AND INTERMEDIATE IN THE SYNTHESIS OF «TRIAZIDE» BY HPLC. Drug development & registration. 2017;(2):146-150. (In Russ.)
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