STANDARDIZATION OF THE AMINO ACIDS TABLETS BY DIFFUSE REFLECTION IR SPECTROSCOPY
Abstract
The possibility of using the infrared spectra of the diffuse reflection in the near and medium field of standardization and optimization of the technological process of tablet forms of aliphatic amino acids: butyric, β-alanine, γ-aminobutyric acid. Shown near infrared informative to normalize the moisture content of a substance in the stages of the process, as well as in the finished dosage form. The paper analyzed the descriptiveness of the infrared spectra with respect to the tablet form of gamma-aminobutyric acid, glycine. The spectral data to differentiate the homologous amino acids: γ-aminobutyric, beta-aminopropanoic, and glycine.
About the Authors
A. A. Maryin
Kemerovo State Medical University, Ministry of Healthcare
Russian Federation
Russian Federation
I. G. Tansereva
Kemerovo State Medical University, Ministry of Healthcare
Russian Federation
Russian Federation
Y. G. Chistohin
Kemerovo State Medical University, Ministry of Healthcare
Russian Federation
Russian Federation
References
1. А.С. Сагиян. Энантиомерно чистые небелковые аминокислоты. Способы получения. - М.: Наука. 2010. 342 с.
2. M. Diana, J. Quílez, M. Rafecas. Gamma-aminobutyric acid as a bioactive compound in foods: a review // Journal of Functional Foods. 2014. V. 10. P. 407-420.
3. G. Ding, Y. Hou, J. Peng, Y. Shen. On-line near-infrared spectroscopy optimizing and monitoring biotransformation process of γ-aminobutyric acid // J. Pharm. Anal. 2016. V. 6. P. 171-178.
4. В.П. Кузнецов, Е.В. Салтанова, А.С. Сухих, Ю.А. Фадеев. ИК-спектроскопическое исследование сегнетоэлектрических свойств на примере кроконовой кислоты // Ползуновский вестник. 2013. № 1. С. 52-54.
5. И.В. Потапов, А.С. Сухих. Окислительно-восстановительные свойства комплексных соединений фторхинолонов с ионами меди (II) // Фундаментальная и клиническая медицина. 2016. Т. 1. № 1. С. 39-45.
6. Сильверстейн Р., Вебстер Ф., Кимл Д. Спектрометрическая идентификация органических соединений / Пер. с англ. - М.: БИНОМ. Лаб. знаний, 2011. 557 с.
7. P.K. Ghosh, D.S. Jayas. Use of spectroscopic data for automation in food processing industry. Sens and Instrumen Food Qual. 2009. V. 3. P. 3-11.
Review
For citations:
Maryin A.A., Tansereva I.G., Chistohin Y.G. STANDARDIZATION OF THE AMINO ACIDS TABLETS BY DIFFUSE REFLECTION IR SPECTROSCOPY. Drug development & registration. 2017;(2):156-158. (In Russ.)
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