CHLORIDE-2-[(1Z)-1-(3,5-DIPHENYL-1,3,4-THYADIAZOLE-2(3H)-ILIDEN)METHYL]-3,5-DIPHENYL-1,3,4-THYADIAZOLE-3 AS A PROMISING COMPOUND FOR THE DEVELOPMENT OF NEW DRUGS
Abstract
The method of obtaining new heterocyclic compound - chloride 2-[(1Z)-1-(3,5-diphenyl-1,3,4-thiadiazol-2(3H)-ilidene)methyl]-3,5-diphenyl-1,3,4-thiadiazol-3-Ia was developed. Its structure was proved by physicochemical methods of identification of organic compounds: 1Н- and 13С-NMR-, IR-spectrometry, mass spectrometry. Antifungal activity was defined against С. albicans, T. rubrum, T. mentagrophytes, F. proliferatum, S. brevicaulis . It was shown that this compound has potent antifungal activity and can potentially be used in medicine as antimicrobial with fungicidal action.
About the Authors
A. S. Koshevenko
Federal State Educational Institution of Higher Education «Saint-Petersburg State Chemical-Pharmaceutical Academy» of the Russian Federation Ministry of Health
Russian Federation
Russian Federation
V. N. Yuskovets
Federal State Educational Institution of Higher Education «Saint-Petersburg State Chemical-Pharmaceutical Academy» of the Russian Federation Ministry of Health
Russian Federation
Russian Federation
I. P. Yakovlev
Federal State Educational Institution of Higher Education «Saint-Petersburg State Chemical-Pharmaceutical Academy» of the Russian Federation Ministry of Health
Russian Federation
Russian Federation
E. P. Ananyeva
Federal State Educational Institution of Higher Education «Saint-Petersburg State Chemical-Pharmaceutical Academy» of the Russian Federation Ministry of Health
Russian Federation
Russian Federation
T. L. Semakova
Federal State Educational Institution of Higher Education «Saint-Petersburg State Chemical-Pharmaceutical Academy» of the Russian Federation Ministry of Health
Russian Federation
Russian Federation
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Review
For citations:
Koshevenko A.S., Yuskovets V.N., Yakovlev I.P., Ananyeva E.P., Semakova T.L. CHLORIDE-2-[(1Z)-1-(3,5-DIPHENYL-1,3,4-THYADIAZOLE-2(3H)-ILIDEN)METHYL]-3,5-DIPHENYL-1,3,4-THYADIAZOLE-3 AS A PROMISING COMPOUND FOR THE DEVELOPMENT OF NEW DRUGS. Drug development & registration. 2017;(2):188-190. (In Russ.)
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