RABBIT'S PORTAL VEIN EMBOLISATION METHODS
Abstract
There are a huge of number people with liver tumors. The main method of treatment of this pathology is surgery, in some cases, impossible without prior stimulation of liver regeneration. For these purposes in recent years increasingly used embolization and/or chemoembolization of liver vessels. One of the most common ways - portal vein embolization (PVE). Identification of the benefit - risk ratio for PVE agents is very actually aim of studies in preclinical fields. The aim of this study was to evaluate the methods of administration of the microspheres in the portal vein of the rabbit. As means embolic microspheres used a polyvinyl alcohol with a size 0,1÷0,3 mm. In the course of this work was reproduced method of rabbit’s PVE.
About the Authors
G. V. Vanatiev
CJSC «Saint-Petersburg Institute of Pharmacy»
Russian Federation
Russian Federation
Y. A. Gushchin
CJSC «Saint-Petersburg Institute of Pharmacy»
Russian Federation
Russian Federation
M. A. Goryacheva
CJSC «Saint-Petersburg Institute of Pharmacy»
Russian Federation
Russian Federation
I. E. Makarenko
CJSC «Saint-Petersburg Institute of Pharmacy»
Russian Federation
Russian Federation
M. A. Kovaleva
CJSC «Saint-Petersburg Institute of Pharmacy»
Russian Federation
Russian Federation
M. N. Makarova
CJSC «Saint-Petersburg Institute of Pharmacy»
Russian Federation
Russian Federation
References
1. Рак: Информационный бюллетень, № 297, февраль 2017 / Всемирная организация здравоохранения. URL: http://www.who.int/mediacentre/factsheets/fs297/ru (дата обращения: 11.05.2017).
2. K. Han, J.H Kim. Transarterial chemoembolization in hepatocellular carcinoma treatment: Barcelona clinic liver cancer staging system // World Journal of Gastroenterology. 2015. V. 21(36). P. 10327-10335.
3. V.A. Saraswat, G. Pandey, S. Shetty. Treatment algorithms for managing hepatocellular carcinoma // Journal of Clinical and Experimental Hepatology. 2014. V. 4(S3). P. S80-S89.
4. K.P. Van Lienden. Radiological aspects of portal vein embolization: PhD thesis. - 2012. 231 p.
5. J. W. Van den Esschert, K.P. Van Lienden, W. De Graaf, M.A.W. Maas, J.J.T.H Roelofs, M. Heger, T.M. Van Gulik. Portal vein embolization induces more liver regeneration than portal vein ligation in a standardized rabbit model // Surgery. 2011. V. 149(3). P. 378-385.
6. П.Г. Таразов, Д.А. Гранов, А.А. Поликарпов. Предоперационная эмболизация воротной вены у больных злокачественными опухолями печени // Альманах Института хирургии имени А.В. Вишневского. 2008. Т. 3. № 3. С. 23-28.
7. F. Huisman, K.P. Van Lienden, S. Damude, L.T. Hoekstra, T.M. Van Gulik. A review of animal models for portal vein embolization // Journal of Surgical Research. 2014. V. 191. P. 179-188.
8. W. De Graaf, J.W. Van den Esschert, K.P. Van Lienden, J.J. Roelofs, T.M. Van Gulik. A rabbit model for selective portal vein embolization // Journal of Surgical Research. 2011. V. 171. P. 486-494.
9. L.T. Hoekstra, K.P. Van Lienden, J. Verheij, C.M. Van Der Loos, M. Heger, T.M. Van Gulik. Enhanced tumor growth after portal vein embolization in a rabbit tumor model // Journal of Surgical Research. 2013. V. 180(1). P. 89-96.
10. Guidelines for Rodent & Rabbit Anesthesia, Analgesia and Tranquilization & Euthanasia Methods // Tulane University IACUC. URL: https://tulane.edu/asvpr/iacuc/hsc/upload/Rodent-Rabbit-anesthesia-guidelines.pdf (дата обращения: 11.06.2017).
Review
For citations:
Vanatiev G.V., Gushchin Y.A., Goryacheva M.A., Makarenko I.E., Kovaleva M.A., Makarova M.N. RABBIT'S PORTAL VEIN EMBOLISATION METHODS. Drug development & registration. 2017;(3):152-155. (In Russ.)
Views:
476
Email this article 