SYNTHESIS OF BENDAMUSTINE HYDROCHLORIDE IN FLOW MICROREACTOR
Abstract
The possibility and prospects of carrying out the chlorination step in the scheme for the synthesis of bendamustine hydrochloride were investigated. The advantages and prospects of the process in the flow microreactor are shown. The conditions for conducting the process in the flow microreactor under which the chlorination reaction proceeds with a lower content of by-products and a higher yield are chosen.
About the Authors
A. Moldavsky
CJSC Biocad;
St. Petersburg Chemical-Pharmaceutical Academy of the Ministry of Healthcare of Russia
Russian Federation
Russian Federation
A. M. Yurakov
CJSC Biocad;
St. Petersburg Chemical-Pharmaceutical Academy of the Ministry of Healthcare of Russia
Russian Federation
Russian Federation
M. B. Supurghibekov
CJSC Biocad
Russian Federation
Russian Federation
P. I. Elagin
CJSC Biocad
Russian Federation
Russian Federation
B. Yu. Lalaev
St. Petersburg Chemical-Pharmaceutical Academy of the Ministry of Healthcare of Russia
Russian Federation
Russian Federation
I. A. Fridman
St. Petersburg Chemical-Pharmaceutical Academy of the Ministry of Healthcare of Russia
Russian Federation
Russian Federation
References
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Review
For citations:
Moldavsky A., Yurakov A.M., Supurghibekov M.B., Elagin P.I., Lalaev B.Yu., Fridman I.A. SYNTHESIS OF BENDAMUSTINE HYDROCHLORIDE IN FLOW MICROREACTOR. Drug development & registration. 2017;(4):148-152. (In Russ.)
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