ANALYSIS OF STRUCTURAL FEATURES OF THE KETO-KETAL ISOMERS OF WARFARIN BY SPECTRAL METHODS
Abstract
As a result of the studies was shown that the relative ratios of isomers by integration in DMSO-d6: (S, R)-warfarin – (S, S)-warfarin – open chain warfarin are 70%: 28%: 2%; in СDCl3 are 45%: 40%: 15%. In the IR spectra of warfarin specific absorption bands are observed in the regions 3271–3277 cm-1, 1681–1682 cm-1, 1103–1076 cm-1, corresponding to:νOH, νCH=CH: νas C–O–C. The molecular peak of warfarin after silylation has m/z 380 corresponding to the mass of trimethylsilyl-warfarin. Thus, the possibility of using IR, NMR spectroscopy and chromatography-mass spectrometry to confirm the authenticity of warfarin derivatives has been demonstrated.
About the Authors
A. Z. Abyshev
St. Petersburg Chemical and Pharmaceutical Academy, Ministry of Healthcare
Russian Federation
Russian Federation
K. B. Nguyen
St. Petersburg Chemical and Pharmaceutical Academy, Ministry of Healthcare
Russian Federation
Russian Federation
L. N. Zinchuk
St. Petersburg Chemical and Pharmaceutical Academy, Ministry of Healthcare
Russian Federation
Russian Federation
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Review
For citations:
Abyshev A.Z., Nguyen K.B., Zinchuk L.N. ANALYSIS OF STRUCTURAL FEATURES OF THE KETO-KETAL ISOMERS OF WARFARIN BY SPECTRAL METHODS. Drug development & registration. 2018;(1):138-145. (In Russ.)
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