BIOLOGICAL ACTIVITY OF HYDROGENALIDES OF AMIDEZONE
Abstract
The biological activity of a number of N'-arylbenzenecarbоximidohydrazide hydrohalides in vitro against Staphylococcus aureus, Bacillus cereus, Escherichia coli and Candida albicans and Aspergillus brasiliensis fungi, as well as anti-inflammatory and analgesic activities in vivo has been studied. N'-(4-nitrophenyl)benzenecarboximidohydrazide hydrochloride (3c) exhibits marked antimicrobial activity against St. aureus, 4-nitro-N'-phenylbenzenecarboximidohydrazide hydrochloride (3b) is effective against C. albicans and A. brasiliensis fungi. Acute toxicity of the obtained compounds for mice with intragastric administration was 1000 to 2000 mg/kg and intraperitoneal administration was 200 to 400 mg/kg. 4-nitro-N'-phenylbenzenecarboximidohydrazide hydrochloride (3b) has anti-inflammatory and analgesic activities that do not exceed that of the reference preparations.
About the Authors
A. S. Senina
St. Petersburg Chemical and Pharmaceutical Academy
Russian Federation
Russian Federation
A. V. Moskvin
St. Petersburg Chemical and Pharmaceutical Academy
Russian Federation
Russian Federation
S. V. Gurina
St. Petersburg Chemical and Pharmaceutical Academy
Russian Federation
Russian Federation
E. L. Avinirova
St. Petersburg Chemical and Pharmaceutical Academy
Russian Federation
Russian Federation
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Review
For citations:
Senina A.S., Moskvin A.V., Gurina S.V., Avinirova E.L. BIOLOGICAL ACTIVITY OF HYDROGENALIDES OF AMIDEZONE. Drug development & registration. 2018;(1):180-185. (In Russ.)
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