DEVELOPMENT AND STANDARDIZATION OF GRANULES IN HARD GELATIN CAPSULES BASED ON THE COMPOSITION OF DRY EXTRACTS OF BIDENS TRIPARTITA, SOLIDAGO CANADENSIS L. AND AGRIMONIA EUPATORIA HERBS
Abstract
The aim of the study is the development and standardization of granules in hard gelatin capsules based on the composition of dry extracts of Bidens tripartita L., Solidago canadensis L. and Agrimonia eupatoria L. herbs, possessing nephroprotective activity and antifibrotics in toxic nephropathies. Developed the structure and defined the quality indicators of the pellets with dry extracts of Bidens tripartita L., Solidago canadensis L. and Agrimonia eupatoria L. herbs. The quality specification for the drug - granules of the composition of dry extracts in solid gelatin capsules is developed.
About the Authors
E. K. Novikova
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
D. A. Chachin
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
I. E. Kaukhova
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
S. A. Minina
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
References
1. Apolihin O. I., Sikov A. V., Moschkaleva N. G., Solnceva T. V., Komarova V. A. Analysis of uronephrological morbidity and mortality in the Russian Federation over a ten-year period (2302-2012) according to official statistics // Experimental and Clinical Urology. 2014. № 2. P. 4-13.
2. Gosudarstvennaja farmakopeja Rossijskoj Federacii. XIII izd. State Pharmacopoeia of the Russian Federation. XIII ed. - М., 2015. В 3-р ср. T. 1. / MZ RF. M., 2015. 1470 p.
3. Gubanov I. A., Kiselev K. V.,Novikov V. S.,Tih omirov V. N. Agrimonia eupatoria L. - Agrimonia eupatoria L. - Common cod, or medicinal // In the book: Illustrated determinant of plants in Central Russia. T. 2. Angiosperms (dicotyledons: separate-petal). M., 2004. P. 356.
4. Gubanov I. A., Kiselev K. V., Novikov V. S., Tihomirov V. N. Bidens tripartite L. Bidens tripartite L. - Three-part sequence // In the book: Illustrated determinant of plants in Central Russia. T. 2. Angiosperms (dicotyledons: separate-petal). M. 2004. P. 353.
5. Gubanov I. A., Kiselev K. V.,Novikov V. S.,Tihomirov V. N Solidago Canadensis L. - Solidago Canadensi L. - Canadian Goldenrod // In the book: Illustrated determinant of plants in Central Russia. T. 2. Angiosperms (dicotyledons: separate-petal). M. 2004. P. 487.
6. Sivak K. V., Lesiovskaja E. E., Ozhigova M. G., Hakim Jel’ Mabruki, Novikova E. K. Nephroprotective and antifibrotic activity of the composition of extracts from the aerial parts of agrimonia eupatoria (rosaceae), bidenst ripartita and solidago canadensis (asteraceae) with toxic nephropathy // Plant resources. 2017. №53(2). P. 265-283.
7. Novikova E. K. Kaukhova I. E. Production and standardization of extracts from Bidens tripartite, Solidago Canadensis and Agrimonia eupatoria // Clinical Pharmacology and Drug Therapy Reviews. 2017. V. 15. С. 27.
Review
For citations:
Novikova E.K., Chachin D.A., Kaukhova I.E., Minina S.A. DEVELOPMENT AND STANDARDIZATION OF GRANULES IN HARD GELATIN CAPSULES BASED ON THE COMPOSITION OF DRY EXTRACTS OF BIDENS TRIPARTITA, SOLIDAGO CANADENSIS L. AND AGRIMONIA EUPATORIA HERBS. Drug development & registration. 2018;(4):44-48. (In Russ.)
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