SORPTION-CHROMATICITY DETERMINATION OF ACTIVE INGREDIENTS IN DRUG SUBSTANCE TETRACYCLINE HYDROCHLORIDE AND IN CYANOCOBALAMIN SOLUTION FOR INJECTION
Abstract
The simple and available technique of determination of tetracycline in the form of colored complex with iron(III) ions and B12 vitamin in the form of the colored thiocyanate complex of cobalt(II) after a chemical mineralization of cyanocobalamin is offered. The analytes were separated from the accompanying components by sorption to polyurethane foam based on ethers. The conditions of sorption separation and measurement of analytical signal of these substances are optimized. The obtained results are in satisfactory agreement with data declared by the manufacturer. The adequacy of proposed approach is confirmed by results of indirect X-ray fluorescence analysis of tetracycline drug substance and injection solution B12 vitamin (cyanocobalamin).
About the Authors
A. A. Chaplenko
M.V. Lomonosov Moscow State University, Faculty of Chemistry;
Federal State Budgetary Institution «Scientific Center for Evaluation of Medicinal Products» of the Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
O. V. Monogarova
M.V. Lomonosov Moscow State University, Faculty of Chemistry
Russian Federation
Russian Federation
K. V. Oskolok
M.V. Lomonosov Moscow State University, Faculty of Chemistry
Russian Federation
Russian Federation
S. A. Chaplenko
M.V. Lomonosov Moscow State University, Faculty of Chemistry
Russian Federation
Russian Federation
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Review
For citations:
Chaplenko A.A., Monogarova O.V., Oskolok K.V., Chaplenko S.A. SORPTION-CHROMATICITY DETERMINATION OF ACTIVE INGREDIENTS IN DRUG SUBSTANCE TETRACYCLINE HYDROCHLORIDE AND IN CYANOCOBALAMIN SOLUTION FOR INJECTION. Drug development & registration. 2016;(3):134-137. (In Russ.)
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