METHOD OF SIMANTENOUS DETERMINATION OF AMINOTRIAZOLE, TRIAZOLOPYRIMIDINONE AND NITROTRIAZOLOPIRIMIDINONE - SUBSTRATE AND SEMI-PRODUCTS OF SYNTHESIS OF DRUG «TRIAZID» BY HPLC METHOD
Abstract
A procedure for the simantenous determination of aminotriazole, triazolopyrimidinone and nirotriazolopyrimidinone was developed using the HPLC method with UV detection. To achieve the best chromatographic characteristics, it is proposed to use a column with a grafted aminophase Zorbax NH2 (Agilent Technologies, USA). The possibility of applying the developed methodology for the technological control of the second stage of the drug «Triazid» preparation is established following the results of the validation.
About the Authors
A. V. Baklykov
I.Ya. Postovsky Institute of Organic Synthesis UB of RAS
Russian Federation
Russian Federation
A. A. Tumashov
I.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS;
Ural Federal University named after the first president of Russia B.N. Yeltsin
Russian Federation
Russian Federation
S. K. Kotovskaya
I.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS;
Ural Federal University named after the first president of Russia B.N. Yeltsin
Russian Federation
Russian Federation
E. N. Ulomskiy
I.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS;
Ural Federal University named after the first president of Russia B.N. Yeltsin
Russian Federation
Russian Federation
G. L. Rusinov
I.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS;
Ural Federal University named after the first president of Russia B.N. Yeltsin
Russian Federation
Russian Federation
V. L. Rusinov
I.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS;
Ural Federal University named after the first president of Russia B.N. Yeltsin
Russian Federation
Russian Federation
D. S. Kopchuk
I.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS;
Ural Federal University named after the first president of Russia B.N. Yeltsin
Russian Federation
Russian Federation
O. N. Chupakhin
I.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS;
Ural Federal University named after the first president of Russia B.N. Yeltsin
Russian Federation
Russian Federation
V. N. Charushin
I.Ya. Postovsky Institute of Оrganic Synthesis UB of RAS;
Ural Federal University named after the first president of Russia B.N. Yeltsin
Russian Federation
Russian Federation
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Review
For citations:
Baklykov A.V., Tumashov A.A., Kotovskaya S.K., Ulomskiy E.N., Rusinov G.L., Rusinov V.L., Kopchuk D.S., Chupakhin O.N., Charushin V.N. METHOD OF SIMANTENOUS DETERMINATION OF AMINOTRIAZOLE, TRIAZOLOPYRIMIDINONE AND NITROTRIAZOLOPIRIMIDINONE - SUBSTRATE AND SEMI-PRODUCTS OF SYNTHESIS OF DRUG «TRIAZID» BY HPLC METHOD. Drug development & registration. 2017;(4):98-102. (In Russ.)
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