TO THE QUESTION OF SYNTHESIS AND STANDARDIZATION OF PHARMACOLOGICALLY ACTIVE PYRIDINE AND PYRROLE DERIVATIVES
Abstract
The pilot studies on derivative synthesis based on pyrrolo-pyridine and pyrrolo-pyrrole groups possessing pharmacological activity have been conducted. Domino reactions principle has been used during the studies. The possibility of physico-chemical methods appliance has been studied in order to standardize the obtained chemical compounds. Synthesized benzyl ether 5-tert-butyl-1-benzyl-2,4-dioxohexahydro-1H-pyrrolo[3,2]pyridine-3a,5-(6H)-dicarboxylate and benzyl ether 5-tert-butyl-2,4-dioxo-1-phenethylhexahydro-1H-pyrrolo[3,2c]-3a,5(6H)-dicarboxylate were isolated by column chromatography (adsorbent - silica gel). The purity of products were monitored by TLC (thin layer chromatography) during the purification steps, eluent cyclohexane:acetone=3:2, sorbent on Silufol silica gel plates.
About the Authors
S. Comesse
Université du Havre
Russian Federation
Russian Federation
Ph. Champetter
Université du Havre
Russian Federation
Russian Federation
Z. M. Sarkissyan
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
A. O. Karasavidi
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
E. N. Kirillova
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
S. Bulangas
Saint-Petersburg State Chemical and Pharmaceutical University
Russian Federation
Russian Federation
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Review
For citations:
Comesse S., Champetter P., Sarkissyan Z.M., Karasavidi A.O., Kirillova E.N., Bulangas S. TO THE QUESTION OF SYNTHESIS AND STANDARDIZATION OF PHARMACOLOGICALLY ACTIVE PYRIDINE AND PYRROLE DERIVATIVES. Drug development & registration. 2018;(2):84-85.
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