The characteristics of gels for oral administration as a dosage form have been considered in the article. A review of medical products and dietary supplements in the form of gels for oral administration available on the Russian market has been presented.

The article provides an overview of the prospects for the development of dry powder inhalers. The advantages and disadvantages of introduction drugs through the lungs are presented in this article. We considered the main farmaceutical research studies finish dosage forms - dry powder inhalers and importance of biopharmaceutical and technological characteristics of this dosage form.

At the moment the task of obtaining high-efficient plant medicinal with wide range of action to be used for pharmaceutical, cosmetic, food industry as a biologically active additives remains valid. The ginseng tissue culture drying parameters impact on the biomass quality (chemistry of biologically active substances and antioxidant activity) is studied in this article. It was identified that increasing temperature and decrease the drying time of ginseng tissue increases antioxidant activity. Qualitative and quantitative analyses confirmed authenticity of the biomass compared to the control (ginseng root tincture).

The article describes the goal of utilization of diatomiceous earth for the impurities of protein nature sedimentation. The experiments done showed and proved the efficiency of diatomiceous earth as a flocculation agent in the insulin fusion protein production. It was shown that insulin fusion protein being in the solution might be easily separated from admixtures by means of isoelectric point sedimentation with a success help of diatomic earth facilitation the precipitation.

The possibility of determining the structural and mechanical properties of ointment and creamy bases, such as the yield point, speed and degree of stress relaxation and thixotropic structure restoration, is described. The proposed method consists in measuring the mechanical stress that occurs when the tester is immersed in a consistency mass. The dependence of the mechanical stress measured in the process of relaxation on the logarithm of time is linear, which makes it simple and convenient to determine the structural and mechanical properties of the test samples.

The present review is devoted to the investigation of immunoadjuvants. The main properties of adjuvants, their species and reasons of the use in vaccines are considered. Adjuvant classification is described.

The present article describes the biochemical mechanisms and the possibility of nucleotides and nucleosides substances naturally produced (i.e. Saccharomyces cerevisiae and others) medicine application in field of correction of pathologically altered metabolic processes in the body under the influence of adverse factors.

The aim of this study is to develop the technology of dry extracts from the roots of Morinda citrifolia as a prospective phyto-active pharmaceutical ingredient (API) for obtaining medicinal products. Factors influencing the extraction process of active ingredients from the roots of Morinda citrifolia were investigated. The modes of extraction were formulated: extraction time of 60 minutes, the hydro-module was established to be 1:30, the extractant - 70% ethyl alcohol. The study developed a technological process of obtaining dry extracts.The technological scheme of production of dry extracts was proffered. The parameters of standardization of the dry extract of Morinda citrifolia roots were established.

In this work are presented the results of analytical method validation of potency assay of serpisten in ointment according to the UF-spectrometry method. A method is validated on such indicators as specificity, range, linearity, trueness and a precision.

The objects of study are Panax ginseng suspension culture, strain Pa.g(B)05ВИЛАР in comparison with the dry extract of Рanax ginseng (Panax Ginseng C.A. Mey). To study the extract of Panax ginseng biologically active properties, we were using the specific enzyme biotest systems in vitro glutathione reductase- and catalase-base. These biotest systems administration can detect respectively compounds with antioxidant, antimicrobial and adaptogenic activity can be detected using complex of these specific enzyme biotest systems. It was found the adaptogenic activity of biologically active substances contained in a dry extract of Рanax ginseng.

The reaction of obtaining N-arylbenzamidines hydrochlorides was studied. The structure of synthesized compounds was proved with the help of modern physicochemical methods of analysis: ¹Н-, ¹³С-spectroscopy, X-ray diffraction analysis (RSA).

The acylation of hydrasine hydrate by amide of carboxyethylalginic acid was studied. The influence of reaction’s temperature, characteristics of mother amide and hydrazine to delivery end of hydrazinocarbonilethylalginic acid were determinated.

Method of determination of potassium cyanate in carbamylated darbepoietin alpha drug substance was developed. The method is based on derivatization of cyanate by methyl ester of anthranilic acid followed by formation bicyclic derivative (1-H,3-H-quinazolinedione), which is able to fluorescence. Application of this method to determine potassium cyanate in protein drugs was investigated. Interference of excipients on this method was evaluated. The validation was performed: specificity, linearity, accuracy, precision, limit of quantitication.

Method of determination of polysorbate 20 and polysorbate 80 in recombinant protein drugs based on spectrophotometry has been designed. Isolation of polysorbate from solution is carried out by solid phase extraction followed by elution of polysorbate with acetonitrile. Acetonitrile solution is evaporated and then polysorbate is derivatized with ferrous-thiocyanate reagent. Obtained derivative is extracted into organic phase and optical density is measured. The most optimal conditions of derivatization, extraction into organic phase and measurment was chosen. The validation was performed: specificity, linearity, accuracy, precision, robustness, limit of quantification.

Glandular trichomes localized on the flowers of some medicinal species of Asteraceae were studied by light microscopy and histochemistry. The trichome morphology and dimensions are presented in the text. The secretory structures have been shown to contain phenolic substances, terpenoids, sesquiterpene lactones. Histochemistry is a perspective method to analyze glandular trichomes of medicinal plants containing essential oil.

Improvement of the quality requirements for the herbal pharmaceutical substances is the basis for the safety and efficacy of drugs produced from it. Modern diagnostic methods made it possible to clarify and to elaborate the regulatory requirements for Fructus Carvi, Fructus Foeniculi and Fructus Anisi vulgaris and to create innovated pharmacopoeial articles.

The main dissolution media recommended for the Dissolution test in Russia and abroad are represented in the review. Possible applications of biorelevant media and media with surfactants are also shown. Based on the analysis of dissolution media authors concluded that it’s necessary to select appropriate dissolution conditions for particular drug. These dissolution conditions should be able to ensure the stability of the active pharmaceutical ingredients throughout the whole stage of the study. Moreover, when developing a dissolution medium, the researcher needs to take into account the chemical structure of the active pharmaceutical ingredients in the drug, the composition of the auxiliary substances and the site of the gastrointestinal tract, where the API dissolves.

There are a huge of number people with liver tumors. The main method of treatment of this pathology is surgery, in some cases, impossible without prior stimulation of liver regeneration. For these purposes in recent years increasingly used embolization and/or chemoembolization of liver vessels. One of the most common ways - portal vein embolization (PVE). Identification of the benefit - risk ratio for PVE agents is very actually aim of studies in preclinical fields. The aim of this study was to evaluate the methods of administration of the microspheres in the portal vein of the rabbit. As means embolic microspheres used a polyvinyl alcohol with a size 0,1÷0,3 mm. In the course of this work was reproduced method of rabbit’s PVE.

The article are presented the results of studying of the pharmacological activity of the dry extract of red grape leaves (Vitis vinifera L.). The extract has showed anti-aggregation, anti-inflammatory, decongestant, analgesic, capillaroprotective properties. The dry extract of red grape leaves can be recommended for clinical trials in diseases associated with vascular disorders, including chronic venous insufficiency.

In the given article, the technique is described and the experimental data for identifying Zaleplon, Zolpidem and Zopiclone (Z-preparations) by method of UV - spectrophotometry isolated from liver tissue are determined. The isolation of Z-preparations was carried out with one of amphiphilic solvents - acetone; purification of impurities - by H-hexane extraction from an acidic medium; TLC was used for additional purification. The Z-preparations were identified by the sequential application of TLC screening and UV-spectrophotometry. The UV-spectrophotometric method was used to determine the quantitative content of the analysis substances. The parameters and validation characteristics of the method were determined, both in the study of native Z-preparations and those isolated from biological objects (linearity, specificity, robustness, and detection limits).

The article presents information about the organization of the process of pharmaceutical development. Developed and described the key steps, stages and procedures make up the process of pharmaceutical development. Presented and systematized the methodology used at each stage of the process of pharmaceutical development. Comparative analysis of methods and found that the minimum number of methods are presented to reflect the process approach to pharmaceutical development phase and the implementation phase in the production of new drugs, including scaling. These steps require detailed study because they require more time and economic costs.

Comparative analysis of pharmacopoeial requirements for dosage forms tablets has been made due to the introduction of the State Pharmacopoeia of the Russian Federation XIII edition. An overview of changed requirements can be useful for revision (reissue) of monographs and normative documentation for tablets.

The paper presents literature data on the history of the finding of Ebers' papyrus and its further study. Its contents are disclosed: the diseases that were known to ancient doctors are listed, the list of medicines used by Egyptian doctors is presented, and technological methods for their preparation are indicated. On the basis of the data presented, it was concluded that it was in Egypt that the «Base of Medicines» was born, which was later used by the doctors of Ancient Greece, Ancient Rome and later by the Aesculapius of Europe.